| 9/3/2015 | Eastern Illinois (7-5) | 5 | at | Western Illinois | 33 | OVC | ||
| 9/12/2015 | Western Illinois | 0 | at | Illinois (5-7) | 44 | at B10 | ||
| 9/19/2015 | Western Illinois | 27 | at | Coastal Carolina (9-3) | 34 | at BigS | ||
| 10/3/2015 | Southern Illinois (3-8,2-6) | 36 | at | Western Illinois | 37 | |||
| 10/10/2015 | South Dakota (5-6,3-5) | 21 | at | Western Illinois | 40 | |||
| 10/17/2015 | Western Illinois | 24 | at | Northern Iowa (9-5,5-4) | 19 | |||
| 10/24/2015 | Western Illinois | 28 | at | Illinois State (10-3,8-1) | 48 | |||
| 10/31/2015 | Youngstown State (5-6,3-5) | 23 | at | Western Illinois | 21 | |||
| 11/7/2015 | Western Illinois | 7 | at | North Dakota State (13-2,8-1) | 59 | |||
| 11/14/2015 | Western Illinois | 37 | at | Indiana State (5-6,3-5) | 30 | OT | ||
| 11/21/2015 | South Dakota State (8-4,5-3) | 24 | at | Western Illinois | 30 | 2OT | ||
| 11/28/2015 | Western Illinois | 24 | at | Dayton (10-2) | 7 | FCS Playoff Round 1 | at Pio | |
| 12/5/2015 | Western Illinois | 19 | at | Illinois State (10-3,8-1) | 36 | FCS Playoff Round 2 |
| vs Western Illinois | vs Other Opponents | Western Illinois compared to OOs | |
| Record: | 6-7 | 91-53 | |
| Points Scored: | 29.69 | 30.01 | 0.32 |
| Points Allowed: | 25.15 | 22.67 | 2.48 |
| Margin: | 4.54 | 7.34 | 2.80 |
| Total Points: | 54.84 | 52.68 | 2.16 |