| 9/1/2012 | North Carolina A&T | 13 | at | Coastal Carolina | 29 | vs MEAC | ||
| VMI | 10 | at | Delaware State | 17 | @ MEAC | |||
| Wofford | 34 | at | Gardner-Webb | 7 | vs SoCon | |||
| Brevard | 10 | at | Presbyterian | 45 | vs SAC (D2) | |||
| Central Conn | 17 | at | Stony Brook | 49 | vs NE | |||
| Charleston Southern | 14 | at | The Citadel | 49 | @ SoCon | |||
| Liberty | 17 | at | Wake Forest | 20 | @ ACC (1A) | |||
| 9/8/2012 | Jacksonville | 31 | at | Charleston Southern | 10 | vs Pio | ||
| Coastal Carolina | 47 | at | Furman | 45 | @ SoCon | |||
| Presbyterian | 3 | at | Georgia Tech | 59 | @ ACC (1A) | |||
| Norfolk State | 31 | at | Liberty | 24 | vs MEAC | |||
| Gardner-Webb | 8 | at | Richmond | 41 | @ CAAF | |||
| Pace | 7 | at | Stony Brook | 77 | vs NE10 (D2) | |||
| Chowan | 17 | at | VMI | 24 | vs CIAA (D2) | |||
| 9/15/2012 | Eastern Kentucky | 35 | at | Coastal Carolina | 17 | vs OVC | ||
| Samford | 44 | at | Gardner-Webb | 23 | vs SoCon | |||
| Charleston Southern | 0 | at | Illinois | 44 | @ B10 (1A) | |||
| Liberty | 14 | at | Montana | 34 | @ BSky | |||
| Stony Brook | 17 | at | Syracuse | 28 | @ BigE (1A) | |||
| Presbyterian | 0 | at | Vanderbilt | 58 | @ SEC (1A) | |||
| Richmond | 47 | at | VMI | 6 | vs CAAF | |||
| 9/22/2012 | Lehigh | 28 | at | Liberty | 26 | vs Pat | ||
| VMI | 3 | at | Navy | 41 | @ Ind (1A) | |||
| Gardner-Webb | 10 | at | Pittsburgh | 55 | @ BigE (1A) | |||
| Furman | 31 | at | Presbyterian | 21 | vs SoCon | |||
| Charleston Southern | 23 | at | Shorter | 20 | @ GSC (D2) | |||
| Colgate | 31 | at | Stony Brook | 32 | vs Pat | |||
| Coastal Carolina | 28 | at | Toledo | 38 | @ MAC (1A) | |||
| 9/29/2012 | Coastal Carolina | 14 | at | Appalachian State | 55 | @ SoCon | ||
| Stony Brook | 23 | at | Army | 3 | @ Ind (1A) | |||
| Presbyterian | 28 | at | Davidson | 13 | @ Pio | |||
| 10/6/2012 | Gardner-Webb | 35 | at | Liberty | 42 | |||
| Charleston Southern | 7 | at | Stony Brook | 49 | ||||
| Presbyterian | 7 | at | VMI | 17 | ||||
| 10/13/2012 | VMI | 14 | at | Charleston Southern | 32 | |||
| Stony Brook | 27 | at | Coastal Carolina | 21 | ||||
| MidAmerica Nazarene | 28 | at | Gardner-Webb | 30 | vs HAAC (NAIA) | |||
| Liberty | 56 | at | Presbyterian | 7 | ||||
| 10/20/2012 | Presbyterian | 21 | at | Charleston Southern | 31 | |||
| Concord | 13 | at | Liberty | 21 | vs WVIAC (D2) | |||
| Gardner-Webb | 10 | at | Stony Brook | 41 | ||||
| Coastal Carolina | 34 | at | VMI | 7 | ||||
| 10/27/2012 | Edward Waters | 7 | at | Charleston Southern | 42 | vs NAIAInd (NAIA) | ||
| Liberty | 12 | at | Coastal Carolina | 36 | ||||
| VMI | 7 | at | Gardner-Webb | 38 | ||||
| Stony Brook | 56 | at | Presbyterian | 17 | ||||
| 11/3/2012 | Coastal Carolina | 56 | at | Gardner-Webb | 33 | |||
| Charleston Southern | 12 | at | Liberty | 26 | ||||
| VMI | 7 | at | Stony Brook | 45 | ||||
| 11/10/2012 | Gardner-Webb | 10 | at | Charleston Southern | 28 | |||
| Stony Brook | 14 | at | Liberty | 28 | ||||
| Coastal Carolina | 65 | at | Presbyterian | 7 | ||||
| The Citadel | 27 | at | VMI | 24 | vs SoCon | |||
| 11/17/2012 | Charleston Southern | 20 | at | Coastal Carolina | 41 | |||
| Presbyterian | 15 | at | Gardner-Webb | 21 | ||||
| Liberty | 33 | at | VMI | 14 | ||||
| 11/24/2012 | Coastal Carolina | 24 | at | Bethune-Cookman | 14 | FCS Round 1 | @ MEAC | |
| Villanova | 10 | at | Stony Brook | 20 | FCS Round 1 | vs CAAF | ||
| 12/1/2012 | Stony Brook | 10 | at | Montana State | 16 | FCS Round 2 | @ BSky | |
| Coastal Carolina | 35 | at | Old Dominion | 63 | FCS Round 2 | @ CAAF |