| 9/1/2012 | Youngstown State (7-4) | 31 | at | Pittsburgh | 17 | MVC (1AA) | ||
| 9/6/2012 | Pittsburgh | 10 | at | Cincinnati (10-3,5-2) | 34 | |||
| 9/15/2012 | Virginia Tech (7-6) | 17 | at | Pittsburgh | 35 | ACC | ||
| 9/22/2012 | Gardner-Webb (3-8) | 10 | at | Pittsburgh | 55 | BigS (1AA) | ||
| 10/5/2012 | Pittsburgh | 13 | at | Syracuse (8-5,5-2) | 14 | |||
| 10/13/2012 | Louisville (11-2,5-2) | 45 | at | Pittsburgh | 35 | |||
| 10/20/2012 | Pittsburgh | 20 | at | Buffalo (4-8) | 6 | at MAC | ||
| 10/27/2012 | Temple (4-7,2-5) | 17 | at | Pittsburgh | 47 | |||
| 11/3/2012 | Pittsburgh | 26 | at | Notre Dame (12-1) | 29 | 3OT | at ND | |
| 11/9/2012 | Pittsburgh | 17 | at | Connecticut (5-7,2-5) | 24 | |||
| 11/24/2012 | Rutgers (9-4,5-2) | 6 | at | Pittsburgh | 27 | |||
| 12/1/2012 | Pittsburgh | 27 | at | South Florida (3-9,1-6) | 3 | |||
| 1/5/2013 | Pittsburgh | 17 | vs | Mississippi (7-6) | 38 | BBVA Compass Bowl | vs SEC |
| vs Pittsburgh | vs Other Opponents | Pittsburgh compared to OOs | |
| Record: | 7-6 | 83-64 | |
| Points Scored: | 21.08 | 25.93 | 4.85 |
| Points Allowed: | 26.62 | 23.37 | 3.25 |
| Margin: | -5.54 | 2.56 | 8.10 |
| Total Points: | 47.70 | 49.30 | -1.60 |