| 9/1/2012 | Colgate | 23 | at | Albany NY (9-2) | 40 | at NE | ||
| 9/8/2012 | Colgate | 21 | at | South Dakota (1-10) | 31 | at MVC | ||
| 9/15/2012 | Sacred Heart (2-9) | 14 | at | Colgate | 35 | NE | ||
| 9/22/2012 | Colgate | 31 | at | Stony Brook (10-3) | 32 | at BigS | ||
| 9/29/2012 | Colgate | 47 | at | Yale (2-8) | 24 | at Ivy | ||
| 10/13/2012 | Holy Cross (2-9,2-4) | 35 | at | Colgate | 51 | |||
| 10/20/2012 | Georgetown (5-6,2-4) | 36 | at | Colgate | 57 | |||
| 10/27/2012 | Colgate | 47 | at | Bucknell (3-8,1-5) | 33 | |||
| 11/3/2012 | Lafayette (5-6,2-4) | 41 | at | Colgate | 65 | |||
| 11/10/2012 | Colgate | 35 | at | Lehigh (10-1,5-1) | 24 | |||
| 11/17/2012 | Colgate | 41 | at | Fordham (6-5,3-3) | 39 | |||
| 11/24/2012 | Colgate | 20 | at | Wagner (9-4) | 31 | FCS Round 1 | at NE |
| vs Colgate | vs Other Opponents | Colgate compared to OOs | |
| Record: | 4-8 | 60-63 | |
| Points Scored: | 31.67 | 23.07 | -8.60 |
| Points Allowed: | 39.42 | 22.93 | 16.49 |
| Margin: | -7.75 | 0.14 | 7.89 |
| Total Points: | 71.09 | 46.00 | 25.09 |