| 9/1/2012 | Western Michigan (4-8) | 7 | at | Illinois | 24 | MAC | ||
| 9/8/2012 | Illinois | 14 | at | Arizona State (8-5) | 45 | at P12 | ||
| 9/15/2012 | Charleston Southern (5-6) | 0 | at | Illinois | 44 | BigS (1AA) | ||
| 9/22/2012 | Louisiana Tech (9-3) | 52 | at | Illinois | 24 | WAC | ||
| 9/29/2012 | Penn State (8-4,6-2) | 35 | at | Illinois | 7 | |||
| 10/6/2012 | Illinois | 14 | at | Wisconsin (8-6,5-4) | 31 | |||
| 10/13/2012 | Illinois | 0 | at | Michigan (8-5,6-2) | 45 | |||
| 10/27/2012 | Indiana (4-8,2-6) | 31 | at | Illinois | 17 | |||
| 11/3/2012 | Illinois | 22 | at | Ohio State (12-0,8-0) | 52 | |||
| 11/10/2012 | Minnesota (6-7,2-6) | 17 | at | Illinois | 3 | |||
| 11/17/2012 | Purdue (6-7,3-5) | 20 | at | Illinois | 17 | |||
| 11/24/2012 | Illinois | 14 | at | Northwestern (10-3,5-3) | 50 |
| vs Illinois | vs Other Opponents | Illinois compared to OOs | |
| Record: | 10-2 | 78-60 | |
| Points Scored: | 32.08 | 31.46 | -0.62 |
| Points Allowed: | 16.67 | 26.95 | -10.28 |
| Margin: | 15.41 | 4.51 | -10.90 |
| Total Points: | 48.75 | 58.41 | -9.66 |