| 9/1/2012 | Furman (3-8,2-6) | 21 | at | Samford | 24 | |||
| 9/8/2012 | West Alabama (8-4) | 6 | at | Samford | 34 | GSC (D2) | ||
| 9/15/2012 | Samford | 44 | at | Gardner-Webb (3-8) | 23 | at BigS | ||
| 9/22/2012 | Samford | 25 | at | Western Carolina (1-10,0-8) | 21 | |||
| 9/29/2012 | Samford | 16 | at | Georgia Southern (10-4,6-2) | 35 | |||
| 10/6/2012 | The Citadel (7-4,5-3) | 7 | at | Samford | 38 | |||
| 10/13/2012 | Appalachian State (8-4,6-2) | 28 | at | Samford | 25 | |||
| 10/20/2012 | Samford | 13 | at | Chattanooga (6-5,5-3) | 20 | |||
| 11/3/2012 | Wofford (9-4,6-2) | 17 | at | Samford | 24 | OT | ||
| 11/10/2012 | Samford | 26 | at | Elon (3-8,1-7) | 15 | |||
| 11/17/2012 | Samford | 3 | at | Kentucky (2-10) | 34 | at SEC |
| vs Samford | vs Other Opponents | Samford compared to OOs | |
| Record: | 4-7 | 56-62 | |
| Points Scored: | 20.64 | 27.61 | 6.97 |
| Points Allowed: | 24.73 | 27.78 | -3.05 |
| Margin: | -4.09 | -0.17 | 3.92 |
| Total Points: | 45.37 | 55.39 | -10.02 |