| 9/1/2012 | Toledo | 17 | at | Arizona (8-5) | 24 | OT | at P12 | |
| 9/8/2012 | Toledo | 34 | at | Wyoming (4-8) | 31 | at MW | ||
| 9/15/2012 | Bowling Green (8-5,6-2) | 15 | at | Toledo | 27 | |||
| 9/22/2012 | Coastal Carolina (8-5) | 28 | at | Toledo | 38 | BigS (1AA) | ||
| 9/29/2012 | Toledo | 37 | at | Western Michigan (4-8,2-6) | 17 | |||
| 10/6/2012 | Central Michigan (7-6,4-4) | 35 | at | Toledo | 50 | |||
| 10/13/2012 | Toledo | 52 | at | Eastern Michigan (2-10,1-7) | 47 | |||
| 10/20/2012 | Cincinnati (10-3) | 23 | at | Toledo | 29 | BigE | ||
| 10/27/2012 | Toledo | 25 | at | Buffalo (4-8,3-5) | 20 | |||
| 11/6/2012 | Ball State (9-4,6-2) | 34 | at | Toledo | 27 | |||
| 11/14/2012 | Toledo | 24 | at | Northern Illinois (12-2,9-0) | 31 | |||
| 11/20/2012 | Akron (1-11,0-8) | 23 | at | Toledo | 35 | |||
| 12/15/2012 | Toledo | 15 | vs | Utah State (11-2) | 41 | Famous Idaho Potato Bowl | vs WAC |
| vs Toledo | vs Other Opponents | Toledo compared to OOs | |
| Record: | 4-9 | 84-68 | |
| Points Scored: | 28.38 | 30.24 | 1.86 |
| Points Allowed: | 31.54 | 27.43 | 4.11 |
| Margin: | -3.16 | 2.81 | 5.97 |
| Total Points: | 59.92 | 57.67 | 2.25 |