| 8/31/2012 | Tennessee | 35 | vs | North Carolina State | 21 | Atlanta GA | vs SEC | |
| 9/1/2012 | Clemson | 26 | vs | Auburn | 19 | Atlanta GA | @ SEC | |
| Miami-Florida | 41 | at | Boston College | 32 | ||||
| Florida Intl | 26 | at | Duke | 46 | vs SBC | |||
| Murray State | 3 | at | Florida State | 69 | vs OVC (1AA) | |||
| William & Mary | 6 | at | Maryland | 7 | vs CAAF (1AA) | |||
| Elon | 0 | at | North Carolina | 62 | vs SoCon (1AA) | |||
| Richmond | 19 | at | Virginia | 43 | vs CAAF (1AA) | |||
| Liberty | 17 | at | Wake Forest | 20 | vs BigS (1AA) | |||
| 9/3/2012 | Georgia Tech | 17 | at | Virginia Tech | 20 | OT | ||
| 9/8/2012 | Maine | 3 | at | Boston College | 34 | vs CAAF (1AA) | ||
| Ball State | 27 | at | Clemson | 52 | vs MAC | |||
| North Carolina State | 10 | at | Connecticut | 7 | @ BigE | |||
| Savannah State | 0 | at | Florida State | 55 | vs MEAC (1AA) | |||
| Presbyterian | 3 | at | Georgia Tech | 59 | vs BigS (1AA) | |||
| Miami-Florida | 13 | at | Kansas State | 52 | @ B12 | |||
| Duke | 13 | at | Stanford | 50 | @ P12 | |||
| Maryland | 36 | at | Temple | 27 | @ BigE | |||
| Penn State | 16 | at | Virginia | 17 | vs B10 | |||
| Austin Peay | 7 | at | Virginia Tech | 42 | vs OVC (1AA) | |||
| North Carolina | 27 | at | Wake Forest | 28 | ||||
| 9/15/2012 | Furman | 7 | at | Clemson | 41 | vs SoCon (1AA) | ||
| North Carolina Central | 17 | at | Duke | 54 | vs MEAC (1AA) | |||
| Wake Forest | 0 | at | Florida State | 52 | ||||
| Virginia | 20 | at | Georgia Tech | 56 | ||||
| North Carolina | 34 | at | Louisville | 39 | @ BigE | |||
| Connecticut | 24 | at | Maryland | 21 | vs BigE | |||
| Bethune-Cookman | 10 | at | Miami-Florida | 38 | vs MEAC (1AA) | |||
| South Alabama | 7 | at | North Carolina State | 31 | vs SBC | |||
| Boston College | 13 | at | Northwestern | 22 | @ B10 | |||
| Virginia Tech | 17 | at | Pittsburgh | 35 | @ BigE | |||
| 9/22/2012 | Memphis | 14 | at | Duke | 38 | vs CUSA | ||
| Clemson | 37 | at | Florida State | 49 | ||||
| Miami-Florida | 42 | at | Georgia Tech | 36 | OT | |||
| East Carolina | 6 | at | North Carolina | 27 | vs CUSA | |||
| The Citadel | 14 | at | North Carolina State | 52 | vs SoCon (1AA) | |||
| Virginia | 7 | at | TCU | 27 | @ B12 | |||
| Bowling Green | 0 | at | Virginia Tech | 37 | vs MAC | |||
| Army | 37 | at | Wake Forest | 49 | vs Ind | |||
| Maryland | 21 | at | West Virginia | 31 | @ B12 | |||
| 9/29/2012 | Clemson | 45 | at | Boston College | 31 | |||
| Middle Tenn State | 49 | at | Georgia Tech | 28 | vs SBC | |||
| North Carolina State | 37 | at | Miami-Florida | 44 | ||||
| Idaho | 0 | at | North Carolina | 66 | vs WAC | |||
| Florida State | 30 | at | South Florida | 17 | @ BigE | |||
| Louisiana Tech | 44 | at | Virginia | 38 | vs WAC | |||
| Cincinnati | 27 | vs | Virginia Tech | 24 | Landover MD | vs BigE | ||
| Duke | 34 | at | Wake Forest | 27 | ||||
| 10/6/2012 | Boston College | 31 | at | Army | 34 | @ Ind | ||
| Georgia Tech | 31 | at | Clemson | 47 | ||||
| Virginia | 17 | at | Duke | 42 | ||||
| Wake Forest | 14 | at | Maryland | 19 | ||||
| Virginia Tech | 34 | at | North Carolina | 48 | ||||
| Florida State | 16 | at | North Carolina State | 17 | ||||
| Miami-Florida | 3 | vs | Notre Dame | 41 | Chicago IL | @ ND | ||
| 10/13/2012 | Boston College | 7 | at | Florida State | 51 | |||
| North Carolina | 18 | at | Miami-Florida | 14 | ||||
| Maryland | 27 | at | Virginia | 20 | ||||
| Duke | 20 | at | Virginia Tech | 41 | ||||
| 10/20/2012 | Virginia Tech | 17 | at | Clemson | 38 | |||
| North Carolina | 30 | at | Duke | 33 | ||||
| Boston College | 17 | at | Georgia Tech | 37 | ||||
| North Carolina State | 20 | at | Maryland | 18 | ||||
| Florida State | 33 | at | Miami-Florida | 20 | ||||
| Wake Forest | 16 | at | Virginia | 10 | ||||
| 10/25/2012 | Clemson | 42 | at | Wake Forest | 13 | |||
| 10/27/2012 | Maryland | 17 | at | Boston College | 20 | |||
| Duke | 7 | at | Florida State | 48 | ||||
| BYU | 41 | at | Georgia Tech | 17 | vs Ind | |||
| North Carolina State | 35 | at | North Carolina | 43 | ||||
| 11/1/2012 | Virginia Tech | 14 | at | Miami-Florida | 30 | |||
| 11/3/2012 | Clemson | 56 | at | Duke | 20 | |||
| Georgia Tech | 33 | at | Maryland | 13 | ||||
| Virginia | 31 | at | North Carolina State | 6 | ||||
| Boston College | 14 | at | Wake Forest | 28 | ||||
| 11/8/2012 | Florida State | 28 | at | Virginia Tech | 22 | |||
| 11/10/2012 | Notre Dame | 21 | at | Boston College | 6 | vs ND | ||
| Maryland | 10 | at | Clemson | 45 | ||||
| Georgia Tech | 68 | at | North Carolina | 50 | ||||
| Wake Forest | 6 | at | North Carolina State | 37 | ||||
| Miami-Florida | 40 | at | Virginia | 41 | ||||
| 11/15/2012 | North Carolina | 37 | at | Virginia | 13 | |||
| 11/17/2012 | Virginia Tech | 30 | at | Boston College | 23 | OT | ||
| North Carolina State | 48 | at | Clemson | 62 | ||||
| Duke | 24 | at | Georgia Tech | 42 | ||||
| Florida State | 41 | at | Maryland | 14 | ||||
| South Florida | 9 | at | Miami-Florida | 40 | vs BigE | |||
| Wake Forest | 0 | at | Notre Dame | 38 | @ ND | |||
| 11/24/2012 | South Carolina | 27 | at | Clemson | 17 | vs SEC | ||
| Miami-Florida | 52 | at | Duke | 45 | ||||
| Florida | 37 | at | Florida State | 26 | vs SEC | |||
| Georgia Tech | 10 | at | Georgia | 42 | @ SEC | |||
| Maryland | 38 | at | North Carolina | 45 | ||||
| Boston College | 10 | at | North Carolina State | 27 | ||||
| Virginia | 14 | at | Virginia Tech | 17 | ||||
| Vanderbilt | 55 | at | Wake Forest | 21 | vs SEC | |||
| 12/1/2012 | Florida State | 21 | vs | Georgia Tech | 15 | ACC Championship | ||
| 12/27/2012 | Cincinnati | 48 | vs | Duke | 34 | Belk Bowl | vs BigE | |
| 12/28/2012 | Rutgers | 10 | vs | Virginia Tech | 13 | Russell Athletic Bowl | vs BigE | |
| 12/31/2012 | LSU | 24 | vs | Clemson | 25 | Chick-fil-A Bowl | vs SEC | |
| Southern California | 7 | vs | Georgia Tech | 21 | Hyundai Sun Bowl | vs P12 | ||
| North Carolina State | 24 | vs | Vanderbilt | 38 | Franklin American Mortgage Music City Bowl | @ SEC | ||
| 1/1/2013 | Northern Illinois | 10 | vs | Florida State | 31 | Discover Orange Bowl | vs MAC |