| 9/1/2012 | Tennessee-Martin (8-3) | 20 | at | Memphis | 17 | OVC (1AA) | ||
| 9/8/2012 | Memphis | 28 | at | Arkansas State (10-3) | 33 | at SBC | ||
| 9/15/2012 | Middle Tenn State (8-4) | 48 | at | Memphis | 30 | SBC | ||
| 9/22/2012 | Memphis | 14 | at | Duke (6-7) | 38 | at ACC | ||
| 10/6/2012 | Rice (7-6,4-4) | 10 | at | Memphis | 14 | |||
| 10/13/2012 | Memphis | 7 | at | East Carolina (8-5,7-1) | 41 | |||
| 10/20/2012 | UCF (10-4,7-2) | 35 | at | Memphis | 17 | |||
| 10/27/2012 | Memphis | 13 | at | SMU (7-6,5-3) | 44 | |||
| 11/3/2012 | Memphis | 28 | at | Marshall (5-7,4-4) | 38 | |||
| 11/10/2012 | Tulane (2-10,2-6) | 23 | at | Memphis | 37 | |||
| 11/17/2012 | Memphis | 46 | at | UAB (3-9,2-6) | 9 | |||
| 11/24/2012 | Southern Miss (0-12,0-8) | 24 | at | Memphis | 42 |
| vs Memphis | vs Other Opponents | Memphis compared to OOs | |
| Record: | 8-4 | 66-72 | |
| Points Scored: | 30.25 | 30.64 | 0.39 |
| Points Allowed: | 24.42 | 32.45 | -8.03 |
| Margin: | 5.83 | -1.81 | -7.64 |
| Total Points: | 54.67 | 63.09 | -8.42 |