| 9/8/2012 | Grambling (1-10) | 0 | at | TCU | 56 | SWAC (1AA) | ||
| 9/15/2012 | TCU | 20 | at | Kansas (1-11,0-9) | 6 | |||
| 9/22/2012 | Virginia (4-8) | 7 | at | TCU | 27 | ACC | ||
| 9/29/2012 | TCU | 24 | at | SMU (7-6) | 16 | at CUSA | ||
| 10/6/2012 | Iowa State (6-7,3-6) | 37 | at | TCU | 23 | |||
| 10/13/2012 | TCU | 49 | at | Baylor (8-5,4-5) | 21 | |||
| 10/20/2012 | Texas Tech (8-5,4-5) | 56 | at | TCU | 53 | 2OT | ||
| 10/27/2012 | TCU | 14 | at | Oklahoma State (8-5,5-4) | 36 | |||
| 11/3/2012 | TCU | 39 | at | West Virginia (7-6,4-5) | 38 | 2OT | ||
| 11/10/2012 | Kansas State (11-2,8-1) | 23 | at | TCU | 10 | |||
| 11/22/2012 | TCU | 20 | at | Texas (9-4,5-4) | 13 | |||
| 12/1/2012 | Oklahoma (10-3,8-1) | 24 | at | TCU | 17 | |||
| 12/29/2012 | TCU | 16 | vs | Michigan State (7-6) | 17 | Buffalo Wild Wings Bowl | vs B10 |
| vs TCU | vs Other Opponents | TCU compared to OOs | |
| Record: | 6-7 | 81-71 | |
| Points Scored: | 22.62 | 32.95 | 10.33 |
| Points Allowed: | 28.31 | 28.83 | -0.52 |
| Margin: | -5.69 | 4.12 | 9.81 |
| Total Points: | 50.93 | 61.78 | -10.85 |