| 9/6/2012 | Pittsburgh (6-7,3-4) | 10 | at | Cincinnati | 34 | |||
| 9/15/2012 | Delaware State (6-5) | 7 | at | Cincinnati | 23 | MEAC (1AA) | ||
| 9/29/2012 | Cincinnati | 27 | vs | Virginia Tech (7-6) | 24 | Landover MD | vs ACC | |
| 10/6/2012 | Miami-Ohio (4-8) | 14 | at | Cincinnati | 52 | MAC | ||
| 10/13/2012 | Fordham (6-5) | 17 | at | Cincinnati | 49 | Pat (1AA) | ||
| 10/20/2012 | Cincinnati | 23 | at | Toledo (9-4) | 29 | at MAC | ||
| 10/26/2012 | Cincinnati | 31 | at | Louisville (11-2,5-2) | 34 | |||
| 11/3/2012 | Syracuse (8-5,5-2) | 24 | at | Cincinnati | 35 | |||
| 11/10/2012 | Cincinnati | 34 | at | Temple (4-7,2-5) | 10 | |||
| 11/17/2012 | Rutgers (9-4,5-2) | 10 | at | Cincinnati | 3 | |||
| 11/23/2012 | South Florida (3-9,1-6) | 10 | at | Cincinnati | 27 | |||
| 12/1/2012 | Cincinnati | 34 | at | Connecticut (5-7,2-5) | 17 | |||
| 12/27/2012 | Cincinnati | 48 | vs | Duke (6-7) | 34 | Belk Bowl | vs ACC |
| vs Cincinnati | vs Other Opponents | Cincinnati compared to OOs | |
| Record: | 3-10 | 81-66 | |
| Points Scored: | 18.46 | 26.70 | 8.24 |
| Points Allowed: | 32.31 | 25.06 | 7.25 |
| Margin: | -13.85 | 1.64 | 15.49 |
| Total Points: | 50.77 | 51.76 | -0.99 |