| 9/1/2012 | Murray State | 3 | at | Florida State (12-2) | 69 | at ACC | ||
| 9/8/2012 | Central Arkansas (9-3) | 42 | at | Murray State | 20 | SLC | ||
| 9/15/2012 | Murray State | 28 | at | Missouri State (3-8) | 23 | at MVC | ||
| 9/22/2012 | Murray State | 49 | at | Eastern Illinois (7-5,6-1) | 50 | OT | ||
| 9/29/2012 | Tennessee Tech (3-8,1-7) | 35 | at | Murray State | 70 | |||
| 10/6/2012 | Murray State | 52 | at | Austin Peay (2-9,1-7) | 14 | |||
| 10/13/2012 | Tennessee-Martin (8-3,6-2) | 66 | at | Murray State | 59 | |||
| 10/27/2012 | Murray State | 35 | at | Jacksonville State (6-5,5-3) | 38 | |||
| 11/3/2012 | Tennessee State (8-3,4-3) | 28 | at | Murray State | 49 | |||
| 11/10/2012 | Murray State | 24 | at | Eastern Kentucky (8-3,6-2) | 55 | |||
| 11/17/2012 | SE Missouri State (3-8,2-6) | 35 | at | Murray State | 42 |
| vs Murray State | vs Other Opponents | Murray State compared to OOs | |
| Record: | 6-5 | 63-52 | |
| Points Scored: | 41.36 | 29.12 | -12.24 |
| Points Allowed: | 39.18 | 27.50 | 11.68 |
| Margin: | 2.18 | 1.62 | -0.56 |
| Total Points: | 80.54 | 56.62 | 23.92 |