| 8/28/2010 | Shorter Hawks 7 vs West Alabama 37 (Demopolis AL) | |
| 9/2/2010 | West Alabama 27 @ Arkansas-Monticello Boll Weevils 20 | † |
| 9/18/2010 | Lambuth Eagles 14 @ West Alabama 13 | |
| 9/23/2010 | West Georgia Wolves 7 @ West Alabama 28 | † |
| 9/30/2010 | West Alabama 37 @ Delta State Statesmen 41 | † |
| 10/9/2010 | West Alabama 22 @ Harding Bison 17 | † |
| 10/16/2010 | Henderson State Reddies 38 @ West Alabama 40 | † |
| 10/23/2010 | Arkansas Tech Wonder Boys 26 @ West Alabama 49 | † |
| 10/30/2010 | West Alabama 27 @ Southern Arkansas Muleriders 30 1OT | † |
| 11/6/2010 | West Alabama 23 @ North Alabama Lions 24 | † |
| 11/11/2010 | Valdosta State Blazers 21 @ West Alabama 24 | † |