| 9/4/2010 | Southern Arkansas Muleriders 0 @ Harding 20 | † |
| 9/16/2010 | Harding 21 @ West Georgia Wolves 28 | † |
| 9/25/2010 | Harding 34 @ Oauchita Tigers 37 | † |
| 10/2/2010 | Lambuth Eagles 0 @ Harding 27 | |
| 10/9/2010 | West Alabama Tigers 22 @ Harding 17 | † |
| 10/16/2010 | Harding 38 @ Delta State Statesmen 35 | † |
| 10/23/2010 | Harding 28 @ Henderson State Reddies 33 | † |
| 10/30/2010 | Arkansas-Monticello Boll Weevils 26 @ Harding 33 | † |
| 11/6/2010 | Arkansas Tech Wonder Boys 7 @ Harding 42 | † |
| 11/13/2010 | North Alabama Lions 28 @ Harding 29 | † |