| 9/11/2010 | Lewis & Clark 21 @ Claremont-Mudd-Scripps Staggs 65 | |
| 9/18/2010 | Pomona-Pitzer Sagehens 38 @ Lewis & Clark 63 | |
| 9/25/2010 | Lewis & Clark 20 @ Whitworth Pirates 38 | † |
| 10/2/2010 | Pacific Boxers 0 @ Lewis & Clark 48 | † |
| 10/9/2010 | Menlo Oaks 10 @ Lewis & Clark 31 | |
| 10/23/2010 | Lewis & Clark 68 @ Puget Sound Loggers 64 | † |
| 10/30/2010 | Pacific Lutheran Lutes 35 @ Lewis & Clark 23 | † |
| 11/6/2010 | Lewis & Clark 24 @ Willamette Bearcats 6 | † |
| 11/13/2010 | Linfield Wildcats 52 @ Lewis & Clark 0 | † |