| 9/11/2010 | Pacific Lutheran 27 @ Hamline Pipers 20 | |
| 9/18/2010 | Cal Lutheran Kingsmen 21 @ Pacific Lutheran 35 | |
| 10/2/2010 | Pacific Lutheran 31 @ Puget Sound Loggers 28 | † |
| 10/9/2010 | Whitworth Pirates 21 @ Pacific Lutheran 39 | † |
| 10/16/2010 | Pacific Lutheran 28 @ Menlo Oaks 10 | |
| 10/23/2010 | Linfield Wildcats 35 @ Pacific Lutheran 20 | † |
| 10/30/2010 | Pacific Lutheran 35 @ Lewis & Clark Pioneers 23 | † |
| 11/6/2010 | Pacific Lutheran 50 @ Pacific Boxers 23 | † |
| 11/13/2010 | Willamette Bearcats 21 @ Pacific Lutheran 24 | † |