| 9/4/2010 | Pacific Boxers 19 @ Puget Sound 36 | † |
| 9/11/2010 | Puget Sound 14 @ Occidental Tigers 44 | |
| 9/25/2010 | Whittier Poets 42 @ Puget Sound 39 6OT | |
| 10/2/2010 | Pacific Lutheran Lutes 31 @ Puget Sound 28 | † |
| 10/9/2010 | Linfield Wildcats 55 @ Puget Sound 14 | † |
| 10/16/2010 | Puget Sound 21 @ Willamette Bearcats 52 | † |
| 10/23/2010 | Lewis & Clark Pioneers 68 @ Puget Sound 64 | † |
| 10/30/2010 | Pacific Boxers 31 @ Puget Sound 42 | † |
| 11/13/2010 | Puget Sound 35 @ Whitworth Pirates 63 | † |