| 9/11/2010 | Lewis & Clark Pioneers 21 @ Claremont-Mudd-Scripps 65 | |
| 9/18/2010 | Claremont-Mudd-Scripps 37 @ Pacific Boxers 9 | |
| 10/2/2010 | La Verne Leopards 14 @ Claremont-Mudd-Scripps 20 | † |
| 10/9/2010 | Chapman Panthers 21 @ Claremont-Mudd-Scripps 31 | |
| 10/16/2010 | Claremont-Mudd-Scripps 7 @ Redlands Bulldogs 21 | † |
| 10/23/2010 | Whittier Poets 27 @ Claremont-Mudd-Scripps 30 | † |
| 10/30/2010 | Cal Lutheran Kingsmen 41 @ Claremont-Mudd-Scripps 14 | † |
| 11/6/2010 | Claremont-Mudd-Scripps 33 @ Occidental Tigers 17 | † |
| 11/13/2010 | Claremont-Mudd-Scripps 31 @ Pomona-Pitzer Sagehens 30 | † |