| 9/4/2010 | Lycoming 17 @ Rowan Professors 24 | |
| 9/11/2010 | Westminster PA Titans 10 @ Lycoming 40 | |
| 9/25/2010 | Ithaca Bombers 24 @ Lycoming 26 | |
| 10/2/2010 | King's Monarchs 24 @ Lycoming 31 | † |
| 10/9/2010 | Lycoming 50 @ Albright Lions 0 | † |
| 10/16/2010 | Widener Pride 7 @ Lycoming 31 | † |
| 10/23/2010 | Lycoming 0 @ Delaware Valley Aggies 36 | † |
| 10/30/2010 | Lycoming 14 @ Wilkes Colonels 31 | † |
| 11/6/2010 | Lebanon Valley Flying Dutchmen 28 @ Lycoming 14 | † |
| 11/13/2010 | Lycoming 17 @ Fairleigh Dickinson-Florham Devils 10 | † |