| 9/4/2010 | Utica 78 @ Becker Hawks 19 | |
| 9/11/2010 | Utica 59 @ Castleton State Spartans 22 | |
| 9/18/2010 | Rensselaer Engineers 21 @ Utica 42 | |
| 9/25/2010 | Wilkes Colonels 10 @ Utica 24 | |
| 10/2/2010 | St John Fisher Cardinals 35 @ Utica 24 | † |
| 10/9/2010 | St Lawrence Saints 13 @ Utica 31 | |
| 10/16/2010 | Utica 16 @ Springfield Pride 20 | † |
| 10/30/2010 | Utica 6 @ Ithaca Bombers 30 | † |
| 11/6/2010 | Utica 21 @ Hartwick Hawks 24 | † |
| 11/13/2010 | Alfred Saxons 37 @ Utica 20 | † |