| 9/4/2010 | Wisconsin-Platteville Pioneers 31 @ Buena Vista 2 | |
| 9/11/2010 | Buena Vista 27 vs Peru State Bobcats 7 (Falls City NE) | |
| 9/25/2010 | Simpson Storm 14 @ Buena Vista 33 | † |
| 10/2/2010 | Buena Vista 14 @ Loras Duhawks 17 | † |
| 10/9/2010 | Wartburg Knights 28 @ Buena Vista 0 | † |
| 10/16/2010 | Buena Vista 26 @ Cornell IA Rams 14 | † |
| 10/23/2010 | Luther Norse 26 @ Buena Vista 20 | † |
| 10/30/2010 | Central IA Dutch 35 @ Buena Vista 7 | † |
| 11/6/2010 | Buena Vista 14 @ Coe Kohawks 44 | † |
| 11/13/2010 | Buena Vista 14 @ Dubuque Spartans 21 | † |