| 9/11/2010 | Wheaton 17 @ Albion Britons 6 | |
| 9/18/2010 | Wisconsin-Platteville Pioneers 20 @ Wheaton 51 | |
| 9/25/2010 | Wheaton 61 @ Olivet Comets 14 | |
| 10/2/2010 | Illinois Wesleyan Titans 19 @ Wheaton 29 | † |
| 10/9/2010 | Wheaton 27 @ Elmhurst Bluejays 24 | † |
| 10/16/2010 | North Park Vikings 7 @ Wheaton 52 | † |
| 10/23/2010 | Carthage Red Men 24 @ Wheaton 31 | † |
| 10/30/2010 | Wheaton 20 @ Augustana IL Vikings 14 | † |
| 11/6/2010 | North Central Cardinals 28 @ Wheaton 6 | † |
| 11/13/2010 | Wheaton 46 @ Millikin Big Blue 0 | † |
| 11/20/2010 | Coe Kohawks 21 @ Wheaton 31 (D3 Playoffs Round 1) | |
| 11/27/2010 | Bethel MN Royals 15 @ Wheaton 10 |