| 9/2/2010 | Rockford Regents 7 @ Dubuque 41 | |
| 9/11/2010 | Dubuque 17 @ Wisconsin-Platteville Pioneers 21 | |
| 9/18/2010 | Dubuque 8 @ Central IA Dutch 34 | † |
| 9/25/2010 | Cornell IA Rams 10 @ Dubuque 28 | † |
| 10/2/2010 | Coe Kohawks 24 @ Dubuque 22 | † |
| 10/9/2010 | Dubuque 6 @ Loras Duhawks 14 | † |
| 10/16/2010 | Simpson Storm 7 @ Dubuque 35 | † |
| 10/23/2010 | Dubuque 17 @ Wartburg Knights 55 | † |
| 11/6/2010 | Dubuque 23 @ Luther Norse 30 | † |
| 11/13/2010 | Buena Vista Beavers 14 @ Dubuque 21 | † |