| 9/4/2010 | St Olaf Oles 28 @ Luther 21 | |
| 9/11/2010 | Luther 31 @ Northwestern MN Eagles 7 | |
| 9/18/2010 | Coe Kohawks 42 @ Luther 19 | † |
| 10/2/2010 | Luther 30 @ Simpson Storm 24 | † |
| 10/9/2010 | Cornell IA Rams 21 @ Luther 24 | † |
| 10/16/2010 | Central IA Dutch 45 @ Luther 26 | † |
| 10/23/2010 | Luther 26 @ Buena Vista Beavers 20 | † |
| 10/30/2010 | Luther 18 @ Wartburg Knights 24 | † |
| 11/6/2010 | Dubuque Spartans 23 @ Luther 30 | † |
| 11/13/2010 | Luther 10 @ Loras Duhawks 24 | † |