| 9/4/2010 | Illinois Wesleyan 20 @ Hope Flying Dutchmen 16 | |
| 9/11/2010 | Alma Scots 14 @ Illinois Wesleyan 35 | |
| 9/18/2010 | Illinois Wesleyan 21 @ Aurora Spartans 14 | |
| 10/2/2010 | Illinois Wesleyan 19 @ Wheaton Thunder 29 | † |
| 10/9/2010 | North Park Vikings 0 @ Illinois Wesleyan 42 | † |
| 10/16/2010 | Elmhurst Bluejays 26 @ Illinois Wesleyan 30 | † |
| 10/23/2010 | Illinois Wesleyan 7 @ North Central Cardinals 30 | † |
| 10/30/2010 | Millikin Big Blue 14 @ Illinois Wesleyan 24 | † |
| 11/6/2010 | Carthage Red Men 42 @ Illinois Wesleyan 49 | † |
| 11/13/2010 | Illinois Wesleyan 17 @ Augustana IL Vikings 20 | † |