| 9/4/2010 | Wingate Bulldogs 22 @ Valdosta State 25 | |
| 9/11/2010 | Valdosta State 45 @ Newberry Wolves 17 | |
| 9/18/2010 | Delta State Statesmen 27 @ Valdosta State 23 | † |
| 9/25/2010 | Valdosta State 27 @ Southern Arkansas Muleriders 0 | † |
| 10/2/2010 | Oauchita Tigers 19 @ Valdosta State 21 | † |
| 10/14/2010 | Valdosta State 5 @ North Alabama Lions 0 | † |
| 10/23/2010 | Arkansas-Monticello Boll Weevils 17 @ Valdosta State 21 | † |
| 10/30/2010 | Valdosta State 21 @ Arkansas Tech Wonder Boys 7 | † |
| 11/6/2010 | West Georgia Wolves 19 @ Valdosta State 31 | † |
| 11/11/2010 | Valdosta State 21 @ West Alabama Tigers 24 | † |
| 11/20/2010 | North Alabama Lions 43 @ Valdosta State 20 | † |