| 9/4/2010 | Bucknell 13 @ Duquesne Dukes 17 | |
| 9/11/2010 | Bucknell 3 @ Marist Red Foxes 14 | |
| 9/18/2010 | Dartmouth Corsairs 43 @ Bucknell 20 | |
| 10/2/2010 | Cornell Rams 21 @ Bucknell 12 | |
| 10/9/2010 | Pennsylvania Quakers 31 @ Bucknell 10 | |
| 10/16/2010 | Bucknell 24 @ Georgetown Hoyas 21 | † |
| 10/23/2010 | Bucknell 10 @ Lehigh Mountain Hawks 32 | † |
| 10/30/2010 | Lafayette Leopards 33 @ Bucknell 22 | † |
| 11/6/2010 | Fordham Rams 33 @ Bucknell 21 | † |
| 11/13/2010 | Colgate Red Raiders 31 @ Bucknell 7 | † |
| 11/20/2010 | Bucknell 9 @ Holy Cross Crusaders 34 | † |