| 9/4/2010 | Georgetown 20 @ Davidson Wildcats 10 | |
| 9/11/2010 | Georgetown 28 @ Lafayette Leopards 24 | † |
| 9/18/2010 | Georgetown 35 @ Yale Bulldogs 40 | |
| 9/25/2010 | Holy Cross Crusaders 7 @ Georgetown 17 | † |
| 10/2/2010 | Georgetown 3 @ Colgate Red Raiders 34 | † |
| 10/9/2010 | Wagner Seahawks 22 @ Georgetown 16 | |
| 10/16/2010 | Bucknell Bison 24 @ Georgetown 21 | † |
| 10/23/2010 | Georgetown 20 @ Sacred Heart Pioneers 33 | |
| 10/30/2010 | Georgetown 19 @ Fordham Rams 24 | † |
| 11/13/2010 | Lehigh Mountain Hawks 24 @ Georgetown 7 | † |
| 11/20/2010 | Marist Red Foxes 7 @ Georgetown 14 |