| 9/18/2010 | Lafayette Leopards 14 @ Pennsylvania 19 | |
| 9/25/2010 | Pennsylvania 10 @ Villanova Wildcats 22 | |
| 10/2/2010 | Dartmouth Corsairs 28 @ Pennsylvania 35 | † |
| 10/9/2010 | Pennsylvania 31 @ Bucknell Bison 10 | |
| 10/16/2010 | Columbia Lions 13 @ Pennsylvania 27 | † |
| 10/23/2010 | Pennsylvania 27 @ Yale Bulldogs 20 | † |
| 10/30/2010 | Brown Bears 7 @ Pennsylvania 24 | † |
| 11/6/2010 | Pennsylvania 52 @ Princeton Tigers 10 | † |
| 11/13/2010 | Harvard Crimson 14 @ Pennsylvania 34 | † |
| 11/20/2010 | Pennsylvania 31 @ Cornell Rams 7 | † |