| 9/18/2010 | Georgetown Hoyas 35 @ Yale 40 | |
| 9/25/2010 | Yale 21 @ Cornell Rams 7 | † |
| 10/2/2010 | Albany NY Great Danes 23 @ Yale 20 | |
| 10/9/2010 | Yale 23 @ Dartmouth Corsairs 20 | † |
| 10/16/2010 | Fordham Rams 6 @ Yale 7 | |
| 10/23/2010 | Pennsylvania Quakers 27 @ Yale 20 | † |
| 10/30/2010 | Columbia Lions 28 @ Yale 31 | † |
| 11/6/2010 | Yale 27 @ Brown Bears 24 | † |
| 11/13/2010 | Princeton Tigers 13 @ Yale 14 | † |
| 11/20/2010 | Yale 21 @ Harvard Crimson 28 | † |