| 9/3/2010 | Sacred Heart 28 @ Marist Red Foxes 35 | |
| 9/11/2010 | Robert Morris Colonials 35 @ Sacred Heart 31 | † |
| 9/18/2010 | Sacred Heart 0 @ St Francis PA Fighting Saints 41 | † |
| 9/25/2010 | Sacred Heart 19 @ Dartmouth Corsairs 21 | |
| 10/2/2010 | Central Conn Blue Devils 24 @ Sacred Heart 14 | † |
| 10/9/2010 | Sacred Heart 24 @ Bryant Bulldogs 25 | † |
| 10/16/2010 | Sacred Heart 17 @ Duquesne Dukes 37 | † |
| 10/23/2010 | Georgetown Hoyas 20 @ Sacred Heart 33 | |
| 10/30/2010 | Sacred Heart 26 @ Monmouth NJ Hawks 25 | † |
| 11/6/2010 | Albany NY Great Danes 35 @ Sacred Heart 23 | † |
| 11/20/2010 | Wagner Seahawks 22 @ Sacred Heart 38 | † |