| 9/3/2005 | Duke | 21 | @ | East Carolina | 24 | ||||
| 9/17/2005 | East Carolina | 34 | @ | Wake Forest | 44 | ||||
| 9/24/2005 | East Carolina | 15 | @ | #11 West Virginia | 20 | ||||
| 10/1/2005 | Southern Miss | 33 | @ | East Carolina | 7 | CUSA | |||
| 10/8/2005 | Rice | 28 | @ | East Carolina | 41 | CUSA | |||
| 10/15/2005 | East Carolina | 24 | @ | SMU | 17 | CUSA | |||
| 10/22/2005 | East Carolina | 24 | @ | Memphis | 27 | CUSA | |||
| 10/29/2005 | UCF | 30 | @ | East Carolina | 20 | CUSA | |||
| 11/12/2005 | East Carolina | 13 | @ | Tulsa | 45 | CUSA | |||
| 11/19/2005 | East Carolina | 34 | @ | Marshall | 29 | CUSA | |||
| 11/26/2005 | UAB | 23 | @ | East Carolina | 31 | CUSA |