| 9/1/2005 | Vanderbilt | 24 | @ | Wake Forest | 20 | ||||
| 9/10/2005 | Wake Forest | 3 | @ | Nebraska | 31 | ||||
| 9/17/2005 | East Carolina | 34 | @ | Wake Forest | 44 | ||||
| 9/24/2005 | Maryland | 22 | @ | Wake Forest | 12 | ACC | |||
| 10/1/2005 | #23 Clemson | 27 | @ | Wake Forest | 31 | ACC | |||
| 10/8/2005 | Wake Forest | 24 | @ | #22 Florida St | 41 | ACC | |||
| 10/15/2005 | Wake Forest | 30 | @ | #19 Boston College | 35 | ACC | |||
| 10/22/2005 | North Carolina St | 19 | @ | Wake Forest | 27 | ACC | |||
| 10/29/2005 | Wake Forest | 44 | @ | Duke | 6 | ACC | |||
| 11/5/2005 | Wake Forest | 17 | @ | #24 Georgia Tech | 30 | ACC | |||
| 11/12/2005 | #9 Miami-Florida | 47 | @ | Wake Forest | 17 | ACC |