| 9/3/2005 | Duke | 21 | @ | East Carolina | 24 | ||||
| 9/10/2005 | #11 Virginia Tech | 45 | @ | Duke | 0 | ACC | |||
| 9/17/2005 | VMI | 14 | @ | Duke | 40 | ||||
| 9/24/2005 | Duke | 7 | @ | Virginia | 38 | ACC | |||
| 10/1/2005 | Navy | 28 | @ | Duke | 21 | ||||
| 10/8/2005 | Duke | 7 | @ | #9 Miami-Florida | 52 | ACC | |||
| 10/15/2005 | #24 Georgia Tech | 35 | @ | Duke | 10 | ACC | |||
| 10/22/2005 | #22 Florida St | 55 | @ | Duke | 24 | ACC | |||
| 10/29/2005 | Wake Forest | 44 | @ | Duke | 6 | ACC | |||
| 11/5/2005 | Duke | 20 | @ | #23 Clemson | 49 | ACC | |||
| 11/19/2005 | Duke | 21 | @ | North Carolina | 24 | ACC |