| 9/10/2005 | Southern Miss | 21 | @ | #13 Alabama | 30 | ||||
| 9/17/2005 | McNeese St | 20 | @ | Southern Miss | 48 | ||||
| 10/1/2005 | Southern Miss | 33 | @ | East Carolina | 7 | CUSA | |||
| 10/8/2005 | Tulsa | 34 | @ | Southern Miss | 17 | CUSA | |||
| 10/15/2005 | UCF | 31 | @ | Southern Miss | 52 | CUSA | |||
| 10/21/2005 | Southern Miss | 37 | @ | UAB | 28 | CUSA | |||
| 10/29/2005 | Southern Miss | 17 | @ | North Carolina St | 21 | ||||
| 11/8/2005 | Southern Miss | 27 | @ | Marshall | 24 | OT | CUSA | ||
| 11/13/2005 | Southern Miss | 24 | @ | Houston | 27 | CUSA | |||
| 11/19/2005 | Memphis | 24 | @ | Southern Miss | 22 | CUSA | |||
| 11/26/2005 | Tulane | 7 | @ | Southern Miss | 26 | CUSA | |||
| 12/20/2005 | Southern Miss | 31 | vs | Arkansas St | 19 | New Orleans |