| 8/25/2022 | Clarke | 20 | at | Evangel (7-3,7-3) | 31 | |||
| 9/3/2022 | Missouri Valley (3-8,3-8) | 30 | at | Clarke | 31 | |||
| 9/10/2022 | Clarke | 3 | at | Central Methodist (1-10,1-10) | 0 | |||
| 9/17/2022 | Benedictine KS (11-1,10-1) | 36 | at | Clarke | 18 | |||
| 9/24/2022 | Clarke | 20 | at | Baker (5-6,5-6) | 19 | |||
| 10/1/2022 | MidAmerica Nazarene (7-4,7-4) | 38 | at | Clarke | 24 | |||
| 10/15/2022 | Peru State (6-5,6-5) | 16 | at | Clarke | 9 | |||
| 10/22/2022 | Clarke | 21 | at | Culver-Stockton (5-6,5-6) | 41 | |||
| 10/29/2022 | Graceland (4-7,4-7) | 30 | at | Clarke | 7 | |||
| 11/5/2022 | Clarke | 3 | at | William Penn (3-7,3-7) | 14 | |||
| 11/12/2022 | Clarke | 7 | at | Grand View (13-1,11-0) | 39 |
| vs Clarke | vs Other Opponents | Clarke compared to OOs | |
| Record: | 8-3 | 57-55 | |
| Points Scored: | 26.73 | 23.61 | -3.12 |
| Points Allowed: | 14.82 | 23.46 | -8.64 |
| Margin: | 11.91 | 0.15 | -11.76 |
| Total Points: | 41.55 | 47.07 | -5.52 |