| 8/27/2022 | Peru State | 6 | at | Missouri Valley (3-8,3-8) | 16 | | | |
| 9/3/2022 | Central Methodist (1-10,1-10) | 0 | at | Peru State | 24 | | | |
| 9/10/2022 | Peru State | 7 | at | Benedictine KS (11-1,10-1) | 31 | | | |
| 9/17/2022 | Baker (5-6,5-6) | 14 | at | Peru State | 19 | | | |
| 9/24/2022 | Peru State | 19 | at | MidAmerica Nazarene (7-4,7-4) | 21 | | | |
| 10/1/2022 | Evangel (7-3,7-3) | 28 | at | Peru State | 0 | | | |
| 10/15/2022 | Peru State | 16 | at | Clarke (3-8,3-8) | 9 | | | |
| 10/22/2022 | William Penn (3-7,3-7) | 25 | at | Peru State | 27 | | | |
| 10/29/2022 | Grand View (13-1,11-0) | 31 | at | Peru State | 3 | | | |
| 11/5/2022 | Peru State | 34 | at | Graceland (4-7,4-7) | 19 | | | |
| 11/12/2022 | Culver-Stockton (5-6,5-6) | 12 | at | Peru State | 17 | | | |