| 8/27/2022 | Grand View (13-1,11-0) | 51 | at | Central Methodist | 0 | | | |
| 9/3/2022 | Central Methodist | 0 | at | Peru State (6-5,6-5) | 24 | | | |
| 9/10/2022 | Clarke (3-8,3-8) | 3 | at | Central Methodist | 0 | | | |
| 9/17/2022 | Central Methodist | 20 | at | Graceland (4-7,4-7) | 26 | | | |
| 9/24/2022 | Culver-Stockton (5-6,5-6) | 26 | at | Central Methodist | 7 | | | |
| 10/1/2022 | Central Methodist | 6 | at | William Penn (3-7,3-7) | 9 | | | |
| 10/8/2022 | MidAmerica Nazarene (7-4,7-4) | 27 | at | Central Methodist | 13 | | | |
| 10/15/2022 | Central Methodist | 0 | at | Benedictine KS (11-1,10-1) | 47 | | | |
| 10/29/2022 | Central Methodist | 14 | at | Missouri Valley (3-8,3-8) | 9 | | | |
| 11/5/2022 | Central Methodist | 0 | at | Baker (5-6,5-6) | 28 | | | |
| 11/12/2022 | Evangel (7-3,7-3) | 33 | at | Central Methodist | 0 | | | |