| 8/25/2022 | Clarke | 20 | at | Evangel | 31 | | | |
| 8/27/2022 | Culver-Stockton | 14 | at | Baker | 26 | | | |
| William Penn | 14 | at | Benedictine KS | 34 | | | |
| Grand View | 51 | at | Central Methodist | 0 | | | |
| Graceland | 32 | at | MidAmerica Nazarene | 54 | | | |
| Peru State | 6 | at | Missouri Valley | 16 | | | |
| 9/3/2022 | Missouri Valley | 30 | at | Clarke | 31 | | | |
| MidAmerica Nazarene | 29 | at | Culver-Stockton | 44 | | | |
| Evangel | 35 | at | Graceland | 46 | | | |
| Benedictine KS | 42 | at | Grand View | 44 | | | |
| Central Methodist | 0 | at | Peru State | 24 | | | |
| Baker | 34 | at | William Penn | 14 | | | |
| 9/10/2022 | Grand View | 20 | at | Baker | 0 | | | |
| Peru State | 7 | at | Benedictine KS | 31 | | | |
| Clarke | 3 | at | Central Methodist | 0 | | | |
| Culver-Stockton | 0 | at | Evangel | 26 | | | |
| William Penn | 9 | at | MidAmerica Nazarene | 33 | | | |
| Graceland | 21 | at | Missouri Valley | 28 | OT | | |
| 9/17/2022 | Benedictine KS | 36 | at | Clarke | 18 | | | |
| Missouri Valley | 28 | at | Culver-Stockton | 16 | | | |
| Central Methodist | 20 | at | Graceland | 26 | | | |
| MidAmerica Nazarene | 0 | at | Grand View | 51 | | | |
| Baker | 14 | at | Peru State | 19 | | | |
| Evangel | | at | William Penn | | | CCD | |
| 9/24/2022 | Clarke | 20 | at | Baker | 19 | | | |
| Graceland | 32 | at | Benedictine KS | 72 | | | |
| Culver-Stockton | 26 | at | Central Methodist | 7 | | | |
| Grand View | 27 | at | Evangel | 7 | | | |
| Peru State | 19 | at | MidAmerica Nazarene | 21 | | | |
| William Penn | 21 | at | Missouri Valley | 10 | | | |
| 10/1/2022 | MidAmerica Nazarene | 38 | at | Clarke | 24 | | | |
| Benedictine KS | 45 | at | Culver-Stockton | 16 | | | |
| Baker | 56 | at | Graceland | 42 | | | |
| Missouri Valley | 7 | at | Grand View | 55 | | | |
| Evangel | 28 | at | Peru State | 0 | | | |
| Central Methodist | 6 | at | William Penn | 9 | | | |
| 10/8/2022 | MidAmerica Nazarene | 27 | at | Central Methodist | 13 | | | |
| 10/13/2022 | Grand View | 52 | at | William Penn | 0 | | | |
| 10/15/2022 | Central Methodist | 0 | at | Benedictine KS | 47 | | | |
| Peru State | 16 | at | Clarke | 9 | | | |
| Graceland | 14 | at | Culver-Stockton | 26 | | | |
| Missouri Valley | 16 | at | Evangel | 21 | | | |
| Baker | 14 | at | MidAmerica Nazarene | 20 | | | |
| 10/22/2022 | Evangel | 17 | at | Baker | 12 | | | |
| Clarke | 21 | at | Culver-Stockton | 41 | | | |
| Graceland | 7 | at | Grand View | 48 | | | |
| Benedictine KS | 45 | at | Missouri Valley | 24 | | | |
| William Penn | 25 | at | Peru State | 27 | | | |
| 10/29/2022 | Baker | 20 | at | Benedictine KS | 21 | | | |
| Graceland | 30 | at | Clarke | 7 | | | |
| MidAmerica Nazarene | 13 | at | Evangel | 21 | | | |
| Central Methodist | 14 | at | Missouri Valley | 9 | | | |
| Grand View | 31 | at | Peru State | 3 | | | |
| Culver-Stockton | 49 | at | William Penn | 21 | | | |
| 11/5/2022 | Central Methodist | 0 | at | Baker | 28 | | | |
| Evangel | 7 | at | Benedictine KS | 30 | | | |
| Grand View | 46 | at | Culver-Stockton | 21 | | | |
| Peru State | 34 | at | Graceland | 19 | | | |
| Missouri Valley | 42 | at | MidAmerica Nazarene | 49 | | | |
| Clarke | 3 | at | William Penn | 14 | | | |
| 11/12/2022 | Missouri Valley | 13 | at | Baker | 14 | | | |
| Evangel | 33 | at | Central Methodist | 0 | | | |
| William Penn | 13 | at | Graceland | 48 | | | |
| Clarke | 7 | at | Grand View | 39 | | | |
| Benedictine KS | 43 | at | MidAmerica Nazarene | 21 | | | |
| Culver-Stockton | 12 | at | Peru State | 17 | | | |
| 11/19/2022 | Southwestern | 7 | at | Benedictine KS | 35 | | NAIA Championship Round 1 | KCAC |
| Carroll MT | 14 | at | Grand View | 17 | | NAIA Championship Round 1 | Front |
| 11/26/2022 | Lindsey Wilson | 7 | at | Grand View | 10 | | NAIA Quarterfinal | MSC |
| 12/3/2022 | Keiser | 38 | at | Grand View | 21 | | NAIA Semifinals | Sun |