| 8/27/2022 | William Penn (3-7,3-7) | 14 | at | Benedictine KS | 34 | | | |
| 9/3/2022 | Benedictine KS | 42 | at | Grand View (13-1,11-0) | 44 | | | |
| 9/10/2022 | Peru State (6-5,6-5) | 7 | at | Benedictine KS | 31 | | | |
| 9/17/2022 | Benedictine KS | 36 | at | Clarke (3-8,3-8) | 18 | | | |
| 9/24/2022 | Graceland (4-7,4-7) | 32 | at | Benedictine KS | 72 | | | |
| 10/1/2022 | Benedictine KS | 45 | at | Culver-Stockton (5-6,5-6) | 16 | | | |
| 10/15/2022 | Central Methodist (1-10,1-10) | 0 | at | Benedictine KS | 47 | | | |
| 10/22/2022 | Benedictine KS | 45 | at | Missouri Valley (3-8,3-8) | 24 | | | |
| 10/29/2022 | Baker (5-6,5-6) | 20 | at | Benedictine KS | 21 | | | |
| 11/5/2022 | Evangel (7-3,7-3) | 7 | at | Benedictine KS | 30 | | | |
| 11/12/2022 | Benedictine KS | 43 | at | MidAmerica Nazarene (7-4,7-4) | 21 | | | |
| 11/19/2022 | Southwestern (9-2) | 7 | at | Benedictine KS | 35 | | NAIA Championship Round 1 | KCAC |