| 8/27/2022 | Graceland (4-7,4-7) | 32 | at | MidAmerica Nazarene | 54 | | | |
| 9/3/2022 | MidAmerica Nazarene | 29 | at | Culver-Stockton (5-6,5-6) | 44 | | | |
| 9/10/2022 | William Penn (3-7,3-7) | 9 | at | MidAmerica Nazarene | 33 | | | |
| 9/17/2022 | MidAmerica Nazarene | 0 | at | Grand View (13-1,11-0) | 51 | | | |
| 9/24/2022 | Peru State (6-5,6-5) | 19 | at | MidAmerica Nazarene | 21 | | | |
| 10/1/2022 | MidAmerica Nazarene | 38 | at | Clarke (3-8,3-8) | 24 | | | |
| 10/8/2022 | MidAmerica Nazarene | 27 | at | Central Methodist (1-10,1-10) | 13 | | | |
| 10/15/2022 | Baker (5-6,5-6) | 14 | at | MidAmerica Nazarene | 20 | | | |
| 10/29/2022 | MidAmerica Nazarene | 13 | at | Evangel (7-3,7-3) | 21 | | | |
| 11/5/2022 | Missouri Valley (3-8,3-8) | 42 | at | MidAmerica Nazarene | 49 | | | |
| 11/12/2022 | Benedictine KS (11-1,10-1) | 43 | at | MidAmerica Nazarene | 21 | | | |