| 8/27/2022 | Culver-Stockton | 14 | at | Baker (5-6,5-6) | 26 | | | |
| 9/3/2022 | MidAmerica Nazarene (7-4,7-4) | 29 | at | Culver-Stockton | 44 | | | |
| 9/10/2022 | Culver-Stockton | 0 | at | Evangel (7-3,7-3) | 26 | | | |
| 9/17/2022 | Missouri Valley (3-8,3-8) | 28 | at | Culver-Stockton | 16 | | | |
| 9/24/2022 | Culver-Stockton | 26 | at | Central Methodist (1-10,1-10) | 7 | | | |
| 10/1/2022 | Benedictine KS (11-1,10-1) | 45 | at | Culver-Stockton | 16 | | | |
| 10/15/2022 | Graceland (4-7,4-7) | 14 | at | Culver-Stockton | 26 | | | |
| 10/22/2022 | Clarke (3-8,3-8) | 21 | at | Culver-Stockton | 41 | | | |
| 10/29/2022 | Culver-Stockton | 49 | at | William Penn (3-7,3-7) | 21 | | | |
| 11/5/2022 | Grand View (13-1,11-0) | 46 | at | Culver-Stockton | 21 | | | |
| 11/12/2022 | Culver-Stockton | 12 | at | Peru State (6-5,6-5) | 17 | | | |