| 9/10/2022 | St Francis IL (7-3,7-3) | 14 | at | St Francis IN | 52 | |||
| 9/17/2022 | Judson (2-8,2-8) | 19 | at | St Francis IN | 51 | |||
| 9/24/2022 | St Xavier (9-3,9-1) | 25 | at | St Francis IN | 20 | |||
| 10/1/2022 | St Francis IN | 10 | at | Siena Heights (5-5,5-5) | 13 | |||
| 10/8/2022 | St Francis IN | 53 | at | Madonna (0-11,0-9) | 0 | |||
| 10/15/2022 | Marian IN (9-2,9-1) | 37 | at | St Francis IN | 10 | |||
| 10/22/2022 | St Francis IN | 0 | at | Indiana Wesleyan (10-2,9-0) | 44 | |||
| 10/29/2022 | Taylor (5-6,5-5) | 6 | at | St Francis IN | 44 | |||
| 11/5/2022 | St Francis IN | 19 | at | Lawrence Tech (3-7,3-6) | 24 | |||
| 11/12/2022 | St Francis IN | 10 | at | Concordia MI (5-5,5-4) | 27 |
| vs St Francis IN | vs Other Opponents | St Francis IN compared to OOs | |
| Record: | 6-4 | 49-48 | |
| Points Scored: | 20.90 | 25.33 | 4.43 |
| Points Allowed: | 26.90 | 26.72 | 0.18 |
| Margin: | -6.00 | -1.39 | 4.61 |
| Total Points: | 47.80 | 52.05 | -4.25 |