| 9/3/2022 | Gustavus Adolphus | 62 | at | Buena Vista | 20 | MIA | ||
| St Olaf | 13 | at | Central IA | 44 | MIA | |||
| Cornell IA | 7 | at | Coe | 56 | MidW | |||
| Nebraska Wesleyan | 31 | at | Eureka | 6 | @ NAC | |||
| Presentation | 29 | at | Luther | 6 | NSAA (NAIA) | |||
| Dubuque | 13 | at | Marietta | 14 | @ OAC | |||
| Wartburg | 34 | at | Monmouth IL | 7 | @ MidW | |||
| Loras | 27 | at | Wisconsin-Eau Claire | 30 | @ WIAC | |||
| 9/10/2022 | Loras | 26 | at | Ill. Benedictine | 48 | @ NAC | ||
| Wisconsin-Eau Claire | 13 | at | Central IA | 31 | WIAC | |||
| Wisconsin-La Crosse | 30 | at | Dubuque | 3 | WIAC | |||
| Coe | 24 | at | Hope | 33 | @ MIAA | |||
| Buena Vista | 41 | at | Lakeland | 34 | @ NAC | |||
| Nebraska Wesleyan | 48 | at | Mayville State | 55 | OT | @ NSAA (NAIA) | ||
| Luther | 27 | at | St Olaf | 55 | @ MIA | |||
| Simpson | 21 | at | Waldorf | 54 | @ NSAA (NAIA) | |||
| Wisconsin-Stout | 0 | at | Wartburg | 27 | WIAC | |||
| 9/17/2022 | Coe | 14 | at | Buena Vista | 3 | |||
| Loras | 38 | at | Central IA | 35 | ||||
| Dubuque | 48 | at | Nebraska Wesleyan | 34 | ||||
| Simpson | 14 | at | Wisconsin-Stevens Point | 35 | @ WIAC | |||
| Luther | 0 | at | Wartburg | 62 | ||||
| 9/24/2022 | Simpson | 10 | at | Coe | 48 | |||
| Wartburg | 25 | at | Dubuque | 0 | ||||
| Nebraska Wesleyan | 31 | at | Loras | 49 | ||||
| Buena Vista | 52 | at | Luther | 49 | ||||
| 10/1/2022 | Dubuque | 46 | at | Buena Vista | 16 | |||
| Central IA | 58 | at | Nebraska Wesleyan | 0 | ||||
| Luther | 33 | at | Simpson | 23 | ||||
| Loras | 3 | at | Wartburg | 42 | ||||
| 10/8/2022 | Wartburg | 35 | at | Central IA | 28 | |||
| Simpson | 14 | at | Dubuque | 66 | ||||
| Buena Vista | 0 | at | Loras | 65 | ||||
| Coe | 56 | at | Luther | 10 | ||||
| 10/15/2022 | Central IA | 52 | at | Buena Vista | 27 | |||
| Dubuque | 15 | at | Coe | 14 | ||||
| Loras | 63 | at | Simpson | 21 | ||||
| Nebraska Wesleyan | 0 | at | Wartburg | 65 | ||||
| 10/22/2022 | Simpson | 17 | at | Central IA | 49 | |||
| Luther | 7 | at | Dubuque | 68 | ||||
| Coe | 27 | at | Loras | 17 | ||||
| Buena Vista | 42 | at | Nebraska Wesleyan | 25 | ||||
| 10/29/2022 | Wartburg | 65 | at | Buena Vista | 0 | |||
| Central IA | 31 | at | Coe | 37 | ||||
| Loras | 40 | at | Luther | 21 | ||||
| Nebraska Wesleyan | 41 | at | Simpson | 74 | ||||
| 11/5/2022 | Luther | 13 | at | Central IA | 61 | |||
| Dubuque | 27 | at | Loras | 20 | OT | |||
| Coe | 34 | at | Nebraska Wesleyan | 14 | ||||
| Simpson | 9 | at | Wartburg | 81 | ||||
| 11/12/2022 | Wartburg | 19 | at | Coe | 14 | |||
| Central IA | 24 | at | Dubuque | 21 | ||||
| Nebraska Wesleyan | 28 | at | Luther | 35 | ||||
| Buena Vista | 26 | at | Simpson | 21 | ||||
| 11/19/2022 | Wisconsin-La Crosse | 6 | at | Wartburg | 14 | D3 Championship Round 1 | WIAC | |
| 11/26/2022 | Wartburg | 23 | at | St John's MN | 20 | D3 Playoffs Round 2 | @ MIA | |
| 12/3/2022 | Aurora | 17 | at | Wartburg | 45 | D3 Quarterfinals | NAC | |
| 12/10/2022 | Wartburg | 31 | at | Mount Union | 34 | D3 Semifinal | @ OAC |