| 9/3/2022 | Capital (0-10) | 31 | at | Denison | 48 | OAC | ||
| 9/10/2022 | Denison | 63 | at | Hilbert (0-7) | 0 | at D3Ind | ||
| 9/17/2022 | Oberlin (0-10,0-8) | 10 | at | Denison | 51 | |||
| 9/24/2022 | Denison | 45 | at | Wabash (7-3,6-2) | 42 | |||
| 10/1/2022 | DePauw (9-2,7-1) | 17 | at | Denison | 13 | |||
| 10/8/2022 | Denison | 7 | at | Ohio Wesleyan (6-4,6-2) | 41 | |||
| 10/15/2022 | Hiram (2-8,1-7) | 38 | at | Denison | 41 | |||
| 10/22/2022 | Denison | 28 | at | Wittenberg (5-5,4-4) | 10 | |||
| 11/5/2022 | Denison | 28 | at | Wooster (6-4,4-4) | 14 | |||
| 11/12/2022 | Kenyon (3-7,2-6) | 12 | at | Denison | 49 |
| vs Denison | vs Other Opponents | Denison compared to OOs | |
| Record: | 2-8 | 36-52 | |
| Points Scored: | 21.50 | 28.83 | 7.33 |
| Points Allowed: | 37.30 | 33.45 | 3.85 |
| Margin: | -15.80 | -4.62 | 11.18 |
| Total Points: | 58.80 | 62.28 | -3.48 |