| 9/3/2022 | Hiram | 16 | at | Bethany WV (1-9) | 26 | at TPAC | ||
| 9/10/2022 | Wooster (6-4,4-4) | 49 | at | Hiram | 21 | |||
| 9/17/2022 | DePauw (9-2,7-1) | 44 | at | Hiram | 0 | |||
| 9/24/2022 | Wittenberg (5-5,4-4) | 38 | at | Hiram | 14 | |||
| 10/1/2022 | Hiram | 34 | at | Oberlin (0-10,0-8) | 7 | |||
| 10/15/2022 | Hiram | 38 | at | Denison (8-2,6-2) | 41 | |||
| 10/22/2022 | Kenyon (3-7,2-6) | 34 | at | Hiram | 31 | |||
| 10/29/2022 | Hiram | 23 | at | Wabash (7-3,6-2) | 59 | |||
| 11/5/2022 | Hilbert (0-7) | 27 | at | Hiram | 59 | D3Ind | ||
| 11/12/2022 | Hiram | 21 | at | Ohio Wesleyan (6-4,6-2) | 47 |
| vs Hiram | vs Other Opponents | Hiram compared to OOs | |
| Record: | 8-2 | 37-51 | |
| Points Scored: | 37.20 | 27.66 | -9.54 |
| Points Allowed: | 25.70 | 32.35 | -6.65 |
| Margin: | 11.50 | -4.69 | -16.19 |
| Total Points: | 62.90 | 60.01 | 2.89 |