| 9/1/2022 | Seton Hill (2-9) | 11 | at | Wheeling | 25 | | | PSAC |
| 9/10/2022 | Wheeling | 14 | at | Notre Dame OH (9-3,9-1) | 27 | | | |
| 9/17/2022 | Wheeling | 56 | at | Alderson-Broaddus (0-11,0-10) | 41 | | | |
| 9/24/2022 | Glenville State (7-4,6-4) | 23 | at | Wheeling | 34 | | | |
| 10/1/2022 | Wheeling | 37 | at | West Virginia Wesleyan (1-10,1-9) | 0 | | | |
| 10/8/2022 | UNC Pembroke (5-6,5-5) | 17 | at | Wheeling | 16 | | | |
| 10/15/2022 | Frostburg State (8-3,7-3) | 27 | at | Wheeling | 31 | | | |
| 10/22/2022 | Wheeling | 42 | at | West Liberty (4-7,3-7) | 21 | | | |
| 10/29/2022 | Wheeling | 31 | at | Concord (9-2,8-2) | 62 | | | |
| 11/5/2022 | Charleston WV (6-5,6-4) | 22 | at | Wheeling | 19 | | | |
| 11/12/2022 | Fairmont State (3-8,3-7) | 28 | at | Wheeling | 31 | OT | | |