| 9/1/2022 | American Int'l (1-9) | 7 | at | Frostburg State | 21 | | | NE10 |
| 9/10/2022 | West Virginia State (7-4,6-4) | 7 | at | Frostburg State | 18 | | | |
| 9/17/2022 | Frostburg State | 34 | at | Charleston WV (6-5,6-4) | 28 | | | |
| 9/24/2022 | Concord (9-2,8-2) | 23 | at | Frostburg State | 22 | | | |
| 9/29/2022 | Frostburg State | 9 | at | UNC Pembroke (5-6,5-5) | 10 | | | |
| 10/8/2022 | Notre Dame OH (9-3,9-1) | 30 | at | Frostburg State | 33 | 2OT | | |
| 10/15/2022 | Frostburg State | 27 | at | Wheeling (7-4,6-4) | 31 | | | |
| 10/20/2022 | Fairmont State (3-8,3-7) | 14 | at | Frostburg State | 16 | | | |
| 10/29/2022 | Alderson-Broaddus (0-11,0-10) | 7 | at | Frostburg State | 58 | | | |
| 11/5/2022 | Frostburg State | 37 | at | West Virginia Wesleyan (1-10,1-9) | 0 | | | |
| 11/12/2022 | Frostburg State | 28 | at | West Liberty (4-7,3-7) | 23 | | | |