| 9/1/2022 | Fairmont State | 15 | at | California PA (6-5) | 35 | | | at PSAC |
| 9/8/2022 | Charleston WV (6-5,6-4) | 40 | at | Fairmont State | 38 | 4OT | | |
| 9/17/2022 | Fairmont State | 29 | at | West Virginia State (7-4,6-4) | 34 | | | |
| 9/24/2022 | UNC Pembroke (5-6,5-5) | 23 | at | Fairmont State | 25 | | | |
| 10/1/2022 | Fairmont State | 10 | at | Concord (9-2,8-2) | 9 | | | |
| 10/6/2022 | Fairmont State | 51 | at | Alderson-Broaddus (0-11,0-10) | 7 | | | |
| 10/13/2022 | West Liberty (4-7,3-7) | 27 | at | Fairmont State | 24 | OT | | |
| 10/20/2022 | Fairmont State | 14 | at | Frostburg State (8-3,7-3) | 16 | | | |
| 10/29/2022 | Notre Dame OH (9-3,9-1) | 30 | at | Fairmont State | 6 | | | |
| 11/5/2022 | Glenville State (7-4,6-4) | 38 | at | Fairmont State | 36 | | | |
| 11/12/2022 | Fairmont State | 28 | at | Wheeling (7-4,6-4) | 31 | OT | | |