| 9/4/2022 | Winston-Salem State (3-6) | 21 | vs | Central State | 41 | Canton OH | CIAA | |
| 9/10/2022 | Lincoln PA (2-7) | 26 | at | Central State | 21 | CIAA | ||
| 9/17/2022 | Central State | 23 | at | Bluefield St WV (3-4) | 27 | at D2Ind | ||
| 9/24/2022 | Miles (1-9,1-6) | 34 | at | Central State | 14 | |||
| 10/1/2022 | Central State | 35 | at | Allen (1-8,0-7) | 32 | |||
| 10/8/2022 | Fort Valley State (8-2,7-2) | 32 | at | Central State | 17 | |||
| 10/15/2022 | Central State | 34 | at | Tuskegee (8-3,7-2) | 49 | |||
| 10/22/2022 | Edward Waters (4-6,4-4) | 45 | at | Central State | 13 | |||
| 10/29/2022 | Central State | 31 | at | Lane (5-5,4-4) | 42 | |||
| 11/5/2022 | Kentucky State (4-6,4-4) | 30 | at | Central State | 31 |
| vs Central State | vs Other Opponents | Central State compared to OOs | |
| Record: | 7-3 | 32-53 | |
| Points Scored: | 33.80 | 22.11 | -11.69 |
| Points Allowed: | 26.00 | 27.99 | -1.99 |
| Margin: | 7.80 | -5.88 | -13.68 |
| Total Points: | 59.80 | 50.10 | 9.70 |